Displacement Pumping of Liquids Radially Inward on Centrifugal Microfluidic Platforms in Motion
نویسندگان
چکیده
We describe two novel centrifugal microfluidic platform designs that enable passive pumping of liquids radially inward while the platform is in motion. The first design uses an immiscible liquid to displace an aqueous solution back towards the center of the platform, while the second design uses an arbitrary pumping liquid with a volume of air between it and the solution being pumped. Both designs demonstrated the ability to effectively pump 55% to 60% of the solution radially inward at rotational frequencies as low as 400 rpm (6.7 Hz) to 700 rpm (11.7 Hz). The pumping operations reached completion within 120 s and 400 s respectively. These platform designs for passive pumping of liquids do not require moving parts or complex fabrication techniques. They offer great potential for increasing the number of sequential operations that can be performed on centrifugal microfluidic platforms, thereby reducing a fundamental limitation often associated with these platforms.
منابع مشابه
Centrifugo-dynamic inward pumping of liquids on a centrifugal microfluidic platform.
We present a method to pump liquids in a centrifugal microfluidic spinning disk from a radial outward position to a radial inward position. Centrifugal forces are applied to compress air in a cavity, this way storing pneumatic energy. The cavity is connected to an outlet channel having a lower hydraulic resistance compared to the inlet channel. The stored pneumatic energy is quickly released by...
متن کاملBuoyancy-driven Centripetal Pumping for Nested Sample Preparation in Bioassays
In this paper we present a method of buoyancy-driven centripetal pumping utilizing a heavy, waterimmiscible liquid to displace an aqueous sample radially inwards against the prevailing centrifugal force. Using formerly introduced dissolvable-film valving, we demonstrate metering and bidirectional periodical pumping of a single sample in the radial direction. We then show integrated sample discr...
متن کاملPush pull microfluidics on a multi-level 3D CD.
A technique known as thermo-pneumatic (TP) pumping is used to pump fluids on a microfluidic compact disc (CD) back towards the CD center against the centrifugal force that pushes liquids from the center to the perimeter of the disc. Trapped air expands in a TP air chamber during heating, and this creates positive pressure on liquids located in chambers connected to that chamber. While the TP ai...
متن کاملA Rapid Micromixer for Centrifugal Microfluidic Platforms
This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator p...
متن کاملBatch-mode mixing on centrifugal microfluidic platforms.
We present two novel fluidic concepts to drastically accelerate the process of mixing in batch-mode (stopped-flow) on centrifugal microfluidic platforms. The core of our simple and robust setup exhibits a microstructured disk with a round mixing chamber rotating on a macroscopic drive unit. In the first approach, magnetic beads which are prefilled into the mixing chamber are periodically deflec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Micromachines
دوره 3 شماره
صفحات -
تاریخ انتشار 2012